A NOVEL CLASS OF 1,3-OXATHIOLANE NUCLEOSIDE ANALOGS HAVING POTENT ANTI-HIV ACTIVITY

被引：53
|
作者：
BELLEAU, B
BRASILI, L
CHAN, L
DIMARCO, MP
ZACHARIE, B
NGUYENBA, N
JENKINSON, HJ
COATES, JAV
CAMERON, JM
机构：
[1] BIOCHEM PHARMA INC,531 BLVD PRAIRIES,LAVAL H7V 1B7,PQ,CANADA
[2] GLAXO GRP RES LTD,DEPT VIROL,GREENFORD UB6 0HE,MIDDX,ENGLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(00)80050-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have developed a novel class of 1,3-oxathiolane nucleoside analogues which were evaluated for anti-HIV activity in the MT-4 cell line. BCH-371, the adenine derivative. has been found to exhibit significant anti-HIV activity.
引用
收藏
页码：1723 / 1728
页数：6
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