STUDIES ON THE MECHANISM OF ANTIINFLAMMATORY AND ANTIULCER ACTIVITY OF PLUCHEA-INDICA - PROBABLE INVOLVEMENT OF 5-LIPOOXYGENASE PATHWAY

被引：39
作者：
SEN, T
GHOSH, TK
CHAUDHURI, AKN
机构：
[1] Dept of Pharmaceutical Technology, Jadavpur University Calcutta
来源：
LIFE SCIENCES | 1993年 / 52卷 / 08期
关键词：
D O I：
10.1016/0024-3205(93)90236-V
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of the methanolic fraction of Pluchea indica Less. root extract was evaluated on various models of inflammation and ulcer in vivo to assess the role of P. indica on the 5-lipoxygenase pathway of prostaglandin synthesis. Studies presented here reveal significant antiinflammatory activity of the fraction on Arachidonic acid, Platelet activation factor and Compound 48/80-induced paw oedema. There was significant inhibition of spontaneous as well as compound 48/80-induced histamine release from mast cells. Ulcer studies revealed significant protective action of the fraction on indomethacin, alcohol and indomethacin-alcohol induced ulceration. There was significant decrease of gastric volume and acidity in pylorus ligated rats. Studies also showed, significant protective action of the same on gastric mucosa.
引用
收藏
页码：737 / 743
页数：7
相关论文
共 26 条
[1]   A STUDY ON MORPHOLOGICAL CHANGES AND HISTAMINE RELEASE INDUCED BY COMPOUND 48/80 IN RAT PERITONEAL MAST CELLS [J].
BLOOM, GD ;
HAEGERMARK, O .
EXPERIMENTAL CELL RESEARCH, 1965, 40 (03) :637-+
[2]   LEUKOTRIENES IN INFLAMMATION [J].
BRAY, MA .
AGENTS AND ACTIONS, 1986, 19 (1-2) :87-99
[3]   EFFECT OF SELECTED ANTIINFLAMMATORY AGENTS AND OTHER DRUGS ON ZYMOSAN, ARACHIDONIC-ACID, PAF AND CARRAGEENAN INDUCED PAW EDEMA IN THE MOUSE [J].
CALHOUN, W ;
CHANG, J ;
CARLSON, RP .
AGENTS AND ACTIONS, 1987, 21 (3-4) :306-309
[4]  
CORNE SJ, 1974, J PHYSIOL-LONDON, V242, pP116
[5]   THE PHARMACOLOGY OF ARACHIDONIC ACID-INDUCED RAT PAW EDEMA [J].
DIMARTINO, MJ ;
CAMPBELL, GK ;
WOLFF, CE ;
HANNA, N .
AGENTS AND ACTIONS, 1987, 21 (3-4) :303-305
[6]   ACUTE ANTIINFLAMMATORY AND GASTRIC EFFECTS OF THE SELENO-ORGANIC COMPOUND EBSELEN [J].
LEYCK, S ;
PARNHAM, MJ .
AGENTS AND ACTIONS, 1990, 30 (3-4) :426-431
[7]   ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE STIMULATES LEUKOTRIENE-B4 SYNTHESIS IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES [J].
LIN, AH ;
MORTON, DR ;
GORMAN, RR .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (05) :1058-1065
[8]   PHARMACOLOGICAL STUDY ON PANAX-GINSENG MEYER,C.A. .11. ANTIINFLAMMATORY ACTIVITY OF GINSENOSIDE RO [J].
MATSUDA, H ;
SAMUKAWA, K ;
KUBO, M .
PLANTA MEDICA, 1990, 56 (01) :19-23
[9]   REV 5901 AND LY 171,883 PROTECT RAT GASTRIC-MUCOSA AGAINST ETHANOL-INDUCED DAMAGE [J].
NIELSEN, ST ;
BENINATI, L ;
CHANG, J .
AGENTS AND ACTIONS, 1987, 21 (3-4) :320-322
[10]   STUDIES ON THE EFFECTS OF PLUCHEA-INDICA LESS ROOT EXTRACT ON GASTRODUODENAL ULCER MODELS IN RATS AND GUINEA-PIGS [J].
PAL, S ;
CHAUDHURI, AKN .
PHYTOTHERAPY RESEARCH, 1989, 3 (04) :156-158
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