INCREASE IN D2 DOPAMINE-RECEPTORS IN THE SUBSTANTIA-NIGRA AFTER CHRONIC (-)-SULPIRIDE TREATMENT

被引：15
作者：
STEFANINI, E [1 ]
FRAU, M [1 ]
GESSA, GL [1 ]
机构：
[1] UNIV CAGLIARI,SCH MED,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY
来源：
BRAIN RESEARCH | 1991年 / 555卷 / 02期
关键词：
DOPAMINE AUTORECEPTOR; H-3]SPIROPERIDOL BINDING; (-)-SULPIRIDE; SUBSTANTIA NIGRA; CHRONIC NEUROLEPTIC; UP-REGULATION;
D O I：
10.1016/0006-8993(91)90362-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Changes in D2 dopamine (DA) receptors in the substantia nigra (SN) and caudate nucleus (CN) homogenates were studied in rats following chronic treatment with the specific D2 receptor antagonist (-)-sulpiride (50 mg/kg s.c. twice daily for 8 days). Sixty hours after (-)-sulpiride withdrawal, the B(max) of [H-3]spiroperidol binding (in the presence of 30 nM ketanserine) was found to be increased by 76% and 38% in the SN and CN, respectively. No changes in the K(d)s were observed. The findings suggest that chronic (-)-sulpiride results in the upregulation of DA autoreceptors in the SN.
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页码：340 / 342
页数：3
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