INHIBITORY EFFECT OF CERULEIN ON SALIVARY SECRETION IN MAN

被引：7
作者：
LOGUERCIO, C
COSTATO, D
BLANCO, CD
机构：
[1] Cattedra di Fisiopatologia Digestiva, I Medical School, Naples
来源：
DIGESTION | 1991年 / 48卷 / 03期
关键词：
CERULEIN; PENTAGASTRIN; SALIVARY SECRETION;
D O I：
10.1159/000200684
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin have a similar excitatory effect on gastric secretion in man, but different actions on salivary flow. Caerulein, at increasing doses, inhibits salivary flow. but not the secretion of amylase; this effect is statistically significant at 0.5-mu-g/kg/h which is the same dose that maximally stimulates gastric secretion. The inhibitory effect of caerulein was not reversed by previous injection of papavarin.
引用
收藏
页码：128 / 133
页数：6
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