REGULATION OF CARTILAGE GROWTH BY GROWTH-HORMONE AND INSULIN-LIKE GROWTH FACTOR-I

被引：59
作者：
ISAKSSON, OGP
OHLSSON, C
NILSSON, A
ISGAARD, J
LINDAHL, A
机构：
[1] Department of Physiology, University of Gothenburg, Gothenburg
来源：
PEDIATRIC NEPHROLOGY | 1991年 / 5卷 / 04期
关键词：
GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; EPIPHYSEAL GROWTH PLATE; CHONDROCYTES;
D O I：
10.1007/BF01453680
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
A number of studies have shown that growth hormone (GH) and insulin-like growth factor-I (IGF-I) have important regulatory roles for skeletal growth. However, it has been a matter of controversy whether GH acts directly on cells in the growth plate or if the growth-promoting effects of GH are mediated by liver-derived (endocrine-acting) IGF-I. With the recognition that GH regulates the production of IGF-I in multiple extra-hepatic tissues, autocrine and paracrine functions of IGF-I have been suggested as important components of GH action. This review focuses on recent developments in our understanding of the cellular mechanisms by which GH promotes longitudinal bone growth and the inter-relationship between GH and IGF-I in the growth plate.
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页码：451 / 453
页数：3
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