ANTIPHOSPHOLIPID ANTIBODIES IN UNSELECTED PATIENTS WITH REPEATED ABORTION

被引：46

作者：

BALASCH, J

FONT, J

LOPEZSOTO, A

CERVERA, R

JOVE, I

CASALS, FJ

VANRELL, JA

机构：

[1] Departments of Obstetrics and Gynaecology, 08036 Barcelona, c/Casanova

[2] Internal Medicine, Faculty of Medicine, Hospital Clinic i Provincial, 08036 Barcelona, c/Casanova

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 01期

关键词：

Abortion; Antiphospholipid antibodies; Aspirin; Autoimmunity; Lupus anticoagulant;

D O I：

10.1093/oxfordjournals.humrep.a137038

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We have studied, prospectively, the incidence of several antiphospholipid antibodies (lupus anticoagulant, anti-cardiolipin, anti-phosphatidylserine, anti-phosphatidic acid, anti-phosphatidylinositol and anti-thromboplastin antibodies) in 65 consecutive patients with two or more (range 2-8, mean 3.1) abortions. Lupus anticoagulant activity was detected in seven (10.7%) patients and all of them exhibited other antiphospholipid antibodies. Of the previous pregnancies in these seven women, 88% had ended in spontaneous abortion. Four of them achieved pregnancy after low-dose aspirin therapy was started, and carried successfully to term. It is concluded that antiphospholipid antibodies, namely lupus anticoagulant, should be routinely screened in the recurrent spontaneous aborter. © 1990 Oxford University Press.

引用

页码：43 / 46

页数：4

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