NO EVIDENCE FOR LOSS OF ALLELES AT 11P IN HBV NEGATIVE HEPATOCELLULAR CARCINOMAS

被引：8
作者：
KIECHLESCHWARZ, M
SCHERER, G
KOVACS, G
机构：
[1] NCI,FREDERICK CANC RES FACIL,BIOCHEM PHYSIOL LAB,BLDG 560,FREDERICK,MD 21701
[2] UNIV FREIBURG,INST HUMAN GENET,W-7800 FREIBURG,GERMANY
来源：
GENES CHROMOSOMES & CANCER | 1990年 / 1卷 / 04期
关键词：
D O I：
10.1002/gcc.2870010409
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of the present study was to determine whether loss of DNA sequences at the chromosome arm 11p, where presumed tumor suppressor genes are located, might occur in hepatocellular carcinomas (HCCs) of hepatitis B virus (HBV) negative patients. Normal liver and HCC genotypes were compared at 6 loci on 11p with 7 polymorphic probes detecting 10 restriction length polymorphisms (RFLPs). Each of the 8 paired normal‐tumor tissue samples was informative for at least three different loci on 11p13‐pter. None of them showed loss of constitutional heterozygosity for those markers. The retainment of 11p alleles suggests that mechanisms other than loss of tumor suppressor genes on 11p are involved in hepatocarcinogenesis of HBV negative patients. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：312 / 314
页数：3
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