GLC DETERMINATION OF BUTYLATED HYDROXYANISOLE IN HUMAN-PLASMA AND URINE

被引：12

作者：

ELRASHIDY, R ^{[1
]}

NIAZI, S ^{[1
]}

机构：

[1] UNIV ILLINOIS,MED CTR,COLL PHARM,DEPT PHARM,CHICAGO,IL 60612

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

关键词：

Antioxidants—butylated hydroxyanisole; GLC analysis in plasma and urine; Butylated hydroxyanisole—GLC analysis in plasma and urine; GLC—analysis; butylated hydroxyanisole in plasma and urine;

D O I：

10.1002/jps.2600680134

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A highly sensitive and specific GLC method was developed for the analysis of butylated hydroxyanisole, a commonly used antioxidant. Concentrations below 100 ng/ml could be detected in human plasma and urine. Preliminary pharmacokinetic studies demonstrated that, upon administration of 100 mg po, butylated hydroxyanisole was quickly absorbed and removed from the plasma with a high degree of intersubject variability. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：103 / 104

页数：2

共 11 条

[1] FATE OF BUTYLATED HYDROXYANISOLE IN MAN AND DOG
ASTILL, BD
FASSETT, DW
TERHAAR, CJ
ROUDABUSH, RL
MILLS, J
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1962, 10 (04) : 315 - &
[2] A GAS CHROMATOGRAPHIC METHOD FOR DETERMINATION OF ANTIOXIDANTS BHA, BHT AND ETHOXYQUIN IN AQUEOUS AND IN HYDROCARBON SOLUBLE SAMPLES
CHOY, TK
ALICINO, NJ
QUATTRONE, JJ
[J]. JOURNAL OF CHROMATOGRAPHY, 1963, 12 (02): : 171 - &
[3] CONNING DM, 1970, P EUR SOC STUD DRUG, V11, P203
[4] DETECTION OF PRESENCE OF BHA BY A RAPID SPECTROFLUORIMETRIC SCREENING-PROCEDURE
DILLI, S
ROBARDS, K
[J]. ANALYST, 1977, 102 (1212) : 201 - 205
[5] BINDING OF BUTYLATED HYDROXYANISOLE TO HUMAN-ALBUMIN USING A NOVEL DYNAMIC METHOD
ELRASHIDY, R
NIAZI, S
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (07) : 967 - 970
[6] PAGE BD, 1976, J ASSOC OFF ANA CHEM, V59, P1208
[7] TAKAHASHI DM, 1968, J ASSOC OFF ANA CHEM, V51, P943
[8] TAKAHASHI DM, 1967, J ASSOC OFF ANA CHEM, V50, P880
[9] TAKANAKA A, 1969, SHOKUHIN EISEIGAKU Z, V10, P260
[10] GAS CHROMATOGRAPHIC SEPARATION OF BHA AND BHT
THOMSON, WAB
[J]. JOURNAL OF CHROMATOGRAPHY, 1965, 19 (03): : 599 - &

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