Association between mean platelet volume and severity of disease in patients with obstructive sleep apnea syndrome without risk factors for cardiovascular disease

被引：31

作者：

Karakas, Mustafa Serkan ^{[1
]}

Altekin, Refik Emre ^{[2
]}

Baktir, Ahmet Oguz ^{[4
]}

Kucuk, Murathan ^{[2
]}

Cilli, Aykut ^{[3
]}

Yalcinkaya, Selim ^{[2
]}

机构：

[1] Nigde State Hosp, Dept Cardiol, Nigde, Turkey

[2] Akdeniz Univ, Fac Med, Dept Cardiol, Nigde, Turkey

[3] Akdeniz Univ, Fac Med, Dept Chest Dis, Nigde, Turkey

[4] Kayseri Training & Res Hosp, Dept Cardiol, Kayseri, Turkey

来源：

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY | 2013年 / 41卷 / 01期

关键词：

Cardiovascular diseases; platelet activation; platelet count; sleep apnea; obstructive/complications/diagnosis;

D O I：

10.5543/tkda.2013.42948

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. Platelet activation and aggregation are central processes in the pathophysiology of atherothrombosis. Mean platelet volume (MPV), a determinant of platelet activation, is a newly-emerging risk factor for atherothrombosis. Therefore, we have investigated the possible association between OSAS and MPV. Study design: We selected 30 mild, 32 moderate, and 31 severe OSAS patients and 31 healthy control subjects matched for age, sex, and body mass index. MPV was measured using an automated blood cell counter. Results: The MPV levels were significantly higher in the severe OSA group than in the control group (8.6 +/- 1.1 vs. 7.8 +/- 0.7 fl, p=0.03). There were no significant differences in respect to MPV between controls and patients with mild and moderate OSA (7.8 +/- 0.7 vs. 8.3 +/- 1.2 fl, p=0.2; 7.8 +/- 0.7 vs. 8.4 +/- 1.3 fl, p=0.08) and between patients with mild, moderate, and severe OSA (8.3 +/- 1.2 vs. 8.4 +/- 1.3 vs. 8.6 +/- 1.1 fl, p=0.9). Significant correlations were seen between MPV and apneahypopnea index (r=0.347, p <= 0.001), minimal oxygen saturation (r=-0.224, p=0.03), and the percentage of recording time spent at a oxygen saturation less than 90% (r=0.240, p=0.02). Conclusion: Our results suggest that OSAS patients tend to have relatively increased platelet activation andatherothrombotic risk.

引用

页码：14 / 20

页数：7

共 37 条

[11]

Martin J.F., Platelet heterogeneity in vascular disease, Platelet Heterogeneity: Biology and Pathology, pp. 205-226, (1990)

[12]

Martin J.F., Trowbridge E.A., Salmon G., Plumb J., The biological significance of platelet volume: Its relationship to bleeding time, platelet thromboxane B<sub>2</sub> production and megakaryocyte nuclear DNA concentration, Thrombosis Research, 32, 5, pp. 443-460, (1983)

[13]

Jakubowski J.A., Thompson C.B., Vaillancourt R., Arachidonic acid metabolism by platelets of differing size, British Journal of Haematology, 53, 3, pp. 503-511, (1983)

[14]

Park Y., Schoene N., Harris W., Mean platelet volume as an indicator of platelet activation: Methodological issues, Platelets, 13, 5-6, pp. 301-306, (2002)

[15]

Vizioli L., Muscari S., Muscari A., The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases, Int J Clin Pract, 63, pp. 1509-1515, (2009)

[16]

Netzer N.C., Stoohs R.A., Netzer C.M., Clark K., Strohl K.P., Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome, Annals of Internal Medicine, 131, 7, pp. 485-491, (1999)

[17]

Manni R., Politini L., Ratti M.T., Tartara A., Sleepiness in obstructive sleep apnea syndrome and simple snoring evaluated by the Epworth Sleepiness Scale [1], Journal of Sleep Research, 8, 4, pp. 319-320, (1999)

[18]

Graver M., Mookadam M., Armas D., Bozarth C., Castleberry T., Gannon M., Et al., Identifying patients at risk for obstructive sleep apnea in a primary care practice, J Am Board Fam Med, 24, pp. 152-160, (2011)

[19]

Cifkova R., Erdine S., Fagard R., Farsang C., Heagerty A.M., Kiowski W., Kjeldsen S., Luscher T., Mallion J.M., Mancia G., Poulter N., Rahn K.H., Rodicio J.L., Ruilope L.M., Van Zwieten P., Waeber B., Williams B., Zanchetti A., Practice Guidelines for Primary Care Physicians: 2003 ESH/ESC Hypertension Guidelines, Journal of Hypertension, 21, 10, pp. 1779-1786, (2003)

[20]

Iber C., Ancoli-Israel S., Chesson A., Quan S.F., The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specification, (2007)

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