MOLECULAR-CLONING OF HUMAN BRAIN GLUTAMATE/ASPARTATE TRANSPORTER-II

被引：70
|
作者：
SHASHIDHARAN, P [1 ]
WITTENBERG, I [1 ]
PLAITAKIS, A [1 ]
机构：
[1] CUNY MT SINAI SCH MED,DEPT NEUROL,NEW YORK,NY 10029
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1191卷 / 02期
关键词：
GLUTAMATE TRANSPORTER; CDNA; HUMAN BRAIN STEM; CLONING; SEQUENCE;
D O I：
10.1016/0005-2736(94)90192-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glutamate transporters are membrane-bound proteins which are localized in glial cells and/or pre-synaptic glutamatergic nerve endings and are essential for the removal and termination of action of synaptic glutamate. Several cDNAs encoding glutamate transporters have been isolated from mammalian tissues, including human cerebellum. Here, we screened cDNA libraries derived from human brain stem and cerebellum, and isolated a novel cDNA that encodes for a glutamate transporter. This cDNA predicts a protein which contains 565 amino acids and is homologous to a rat brain Na+-dependent glutamate/aspartate transporter. The new cDNA is expressed in brain and is structurally distinct from the previously reported human glutamate transporter cDNA.
引用
收藏
页码：393 / 396
页数：4
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