SYNTHESIS OF THE TETRASACCHARIDE REPEATING UNIT OF THE ANTIGEN FROM KLEBSIELLA TYPE-2

被引：0

作者：

MISRA, AK ^{[1
]}

ROY, N ^{[1
]}

机构：

[1] INDIAN ASSOC CULTIVAT SCI,DEPT BIOL CHEM,CALCUTTA 700032,W BENGAL,INDIA

来源：

CARBOHYDRATE RESEARCH | 1995年 / 278卷 / 01期

关键词：

OLIGOSACCHARIDE; SYNTHESIS; TETRASACCHARIDE REPEATING UNIT; KLEBSIELLA TYPE 2;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The disaccharide ethyl 2,4,6-tri-O-acetyl-3-O-(2,3,4,6-tetra-O-benzyl-alpha-D-glucopyranosyl)-1-thio-beta-D-glucopyranoside (6) and methyl 2,6-di-O-benzyl-3-O-(methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranosyluronate)-beta-D-mannopyranoside (21) have been synthesized and condensed in the presence of methyl triflate to afford a tetrasaccharide derivative. Removal of protecting groups methyl 3-O-(methyl alpha-D-glucopyranosyluronate)-4-O-(3-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)-beta-D-mannopyranoside (23), the repeating unit of the antigen from Klebsiella type 2, in the form of its methyl ester methyl glycoside.

引用

页码：103 / 111

页数：9

共 28 条

[1]

AUGE C, 1982, CARBOHYD RES, V82, P85

[2]

BOSS R, 1976, ANGEW CHEM, V88, P578

[3]

Brimacombe JS., 1972, METHOD CARBOHYD CHEM, V6, P376

[4] SYNTHESIS OF AN ARTIFICIAL ANTIGEN THAT CORRESPONDS TO A DISACCHARIDE REPEATING UNIT OF THE CAPSULAR POLYSACCHARIDE OF HAEMOPHILUS-INFLUENZAE TYPE-D - A FACILE SYNTHESIS OF METHYL 2-ACETAMIDO-2-DEOXY-BETA-D-MANNOPYRANOSIDE [J].

CLASSON, B ;

GAREGG, PJ ;

OSCARSON, S ;

TIDEN, AK .

CARBOHYDRATE RESEARCH, 1991, 216 :187-196

[5] REGIOSELECTIVE ALKYLATION AND ACYLATION OF CARBOHYDRATES ENGAGED IN METAL-COMPLEXES [J].

EBY, R ;

WEBSTER, KT ;

SCHUERCH, C .

CARBOHYDRATE RESEARCH, 1984, 129 (JUL) :111-120

[6]

Evans M.E., 1980, METHODS CARBOHYDR CH, V8, P313

[7]

GAREGG PJ, 1982, CARBOHYD RES, V108, P97

[8] A NOVEL, REDUCTIVE RING-OPENING OF CARBOHYDRATE BENZYLIDENE ACETALS, WITH UNUSUAL REGIOSELECTIVITY [J].

GAREGG, PJ ;

HULTBERG, H .

CARBOHYDRATE RESEARCH, 1981, 93 (01) :C10-C11

[9] A REGIOSELECTIVE REDUCTIVE RING-OPENING OF 4,6-O-PROP-2-ENYLIDENE ACETALS OF HEXOPYRANOSIDES [J].

GAREGG, PJ ;

HULTBERG, H ;

OSCARSON, S .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (10) :2395-2397

[10]

GRAHAM LC, 1967, BIOCHEMISTRY-US, V6, P2755

← 1 2 3 →