EFFECTS OF EXTRACORPOREAL MEMBRANE-OXYGENATION ON MORPHINE PHARMACOKINETICS IN INFANTS

被引：45

作者：

DAGAN, O

KLEIN, J

BOHN, D

KOREN, G

机构：

[1] HOSP SICK CHILDREN,DEPT CRIT CARE,TORONTO M5G 1X8,ON,CANADA

[2] HOSP SICK CHILDREN,DEPT PEDIAT,DIV CLIN PHARMACOL TOXICOL,TORONTO M5G 1X8,ON,CANADA

[3] HOSP SICK CHILDREN,RES INST,TORONTO M5G 1X8,ON,CANADA

[4] UNIV TORONTO,DEPT PEDIAT,TORONTO,ON,CANADA

[5] UNIV TORONTO,DEPT PHARMACOL,TORONTO,ON,CANADA

来源：

CRITICAL CARE MEDICINE | 1994年 / 22卷 / 07期

关键词：

EXTRACORPOREAL MEMBRANE OXYGENATION; MORPHINE; INFANTS; PHARMACOKINETICS; PHARMACODYNAMICS; SEDATION; DRUG METABOLISM; OPIATES; CRITICAL ILLNESS; PHARMACOLOGY; INTENSIVE CARE UNIT; PEDIATRIC;

D O I：

10.1097/00003246-199407000-00008

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Objectives: To study the effect of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics of morphine in infants. Design: A prospective, comparative study of morphine pharmacokinetics during and after ECMO. Setting: The pediatric intensive care unit at a children's hospital. Patients: Seven infants, aged 1 day to 12 months, requiring ECMO. Intervention: Infusion of morphine. Measurement and Main Results: Steady-state concentrations of morphine were used to generate a morphine clearance rate. Plasma clearance rate of morphine increased from 0.574 +/- 0.3 L/kg/hr to 1.058 +/- 0.727 L/kg/hr after discontinuation of ECMO (p <.01). Two infants experienced a clinical picture consistent with opioid withdrawal. Conclusion: Infants requiring morphine after ECMO may require higher dose rates to maintain adequate sedation.

引用

页码：1099 / 1101

页数：3

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