CYTOKINE GENE-EXPRESSION DURING INFECTION OF MICE LACKING CD4 AND/OR CD8 WITH TRYPANOSOMA-CRUZI

被引：21
|
作者：
ROTTENBERG, ME
SPORRONG, L
PERSSON, I
WIGZELL, H
ORN, A
机构：
[1] Laboratory of Immunology, Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1995年 / 41卷 / 02期
关键词：
D O I：
10.1111/j.1365-3083.1995.tb03549.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The expression of lymphokine genes during infection of virulent (Tulahuen) or mild (CA-I) strains of T. cruzi was studied in mice lacking CD4 and/or CD8 molecules. The increased susceptibility of CD4(-) and CD4(-)CD8(-) mice to infection with CA-I or Tulahuen was paralleled by diminished IFN-gamma mRNA levels. Nitric oxide release and inducible nitric oxide synthase mRNA accumulation by cells from Tulahuen infected CD4(-) mice was also diminished. CD8(-) (but not CD4(-)CD8(-) mice) showed an increased IL-4 and IL-IO mRNA accumulation upon infection with both strains of T. cruzi. A 'T(h)2-like' response (higher IL-4 and IL-10 mRNA to IFN-gamma mRNA ratio), was also observed when cells from noninfected CD8- mice were stimulated with T cell mitogens.
引用
收藏
页码：164 / 170
页数：7
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