A CONVERGENT SYNTHESIS OF 2'-O-METHYL URIDINE

被引：20

作者：

PARMENTIER, G ^{[1
]}

SCHMITT, G ^{[1
]}

DOLLE, F ^{[1
]}

LUU, B ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,CTR NEUROCHIM,CNRS,CHIM ORGAN SUBS NAT LAB,F-67084 STRASBOURG,FRANCE

来源：

TETRAHEDRON | 1994年 / 50卷 / 18期

关键词：

D O I：

10.1016/S0040-4020(01)80693-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of 2'-O-methyl uridine (1) is described. The key steps in our synthesis are: (1) a facile obtention of the 2'-O-methyl sugar synthon using totally selective and efficient methylation conditions; (2) a stereoselective high-yield condensation with an uracil derivative, yielding the desired beta-form.

引用

页码：5361 / 5368

页数：8

共 50 条

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