B7-1 AND B7-2 DO NOT DELIVER IDENTICAL COSTIMULATORY SIGNALS, SINCE B7-2 BUT NOT B7-1 PREFERENTIALLY COSTIMULATES THE INITIAL PRODUCTION OF IL-4

被引：516

作者：

FREEMAN, GJ ^{[1
]}

BOUSSIOTIS, VA ^{[1
]}

ANUMANTHAN, A ^{[1
]}

BERNSTEIN, GM ^{[1
]}

KE, XY ^{[1
]}

RENNERT, PD ^{[1
]}

GRAY, GS ^{[1
]}

GRIBBEN, JG ^{[1
]}

NADLER, LM ^{[1
]}

机构：

[1] REPLIGEN CORP,CAMBRIDGE,MA 02139

来源：

IMMUNITY | 1995年 / 2卷 / 05期

关键词：

D O I：

10.1016/1074-7613(95)90032-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The functional necessity for two CD28 counterreceptors (B7-1 and B7-2) is presently unknown. B7-1 and B7-2 equivalently costimulate IL-2 and interferon-gamma (IFN gamma) production and IL-2 receptor alpha and gamma chain expression. B7-2 induces significantly more IL-4 production than B7-1, with the greatest difference seen in naive T cells. Repetitive costimulation of CD4(+) CD45RA(+) T cells with B7-2 results in moderate levels of both IL-4 and IL-2, whereas repetitive costimulation with B7-1 results in high levels of IL-2 and low levels of IL-4. Therefore, B7-1 and B7-2 costimulation mediate distinct outcomes, since B7-2 provides an initial signal to induce naive T cells to become IL-4 producers, thereby directing the immune response more towards Th0/Th2, whereas B7-1 is a more neutral differentiative signal.

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页码：523 / 532

页数：10

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