REVERSAL OF DOXORUBICIN RESISTANCE BY TETRANDRINE IN CHINESE-HAMSTER OVARY CELL-LINE

被引：0
|
作者：
HE, QY [1 ]
JIANG, B [1 ]
ZHANG, HQ [1 ]
XUE, SB [1 ]
机构：
[1] BEIJING NORMAL UNIV,DEPT BIOL,BEIJING 100875,PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1992年 / 13卷 / 05期
关键词：
TETRANDRINE; DOXORUBICIN; DRUG RESISTANCE; OVARY; TRANSFORMED CELL LINE; CRICETULUS;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Tetrandrine (Tet) 0.5-mu-g . ml-1 and 1 mu-g . ml-1 potentiated 2.88- and 4.3-fold growth-inhibitorY effects of doxorubicin (Dox) in Chinese hamster ovary cell line (CHO), respectively, while Tet 1-mu-g . ml-1 and 2.5-mu-g . ml-1 potentiated 7.3- and 8.4-fold in its resistant cell line (CHO / Dox), respectively. The colony-forming efficiencies were reduced in CHO and CHO / Dox when the cells were treated with noncytotoxic doses of Tet 2.5-mu-g . ml-1 and 5-mu-g . ml-1 in combination with different concentration of Dox. Increase in accumulation of Dox in CHO / Dox cells was shown by fluorometry. The result indicated that Tet reversed the resistance to Dox in CHO / Dox cells.
引用
收藏
页码：416 / 419
页数：4
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