MATERNAL REGULATION OF THE ADRENOCORTICAL-RESPONSE IN PREWEANLING RATS

被引:89
作者
ROSENFELD, P [1 ]
GUTIERREZ, YA [1 ]
MARTIN, AM [1 ]
MALLETT, HA [1 ]
ALLEVA, E [1 ]
LEVINE, S [1 ]
机构
[1] IST SUPER SANITA, FISIOPATOL LAB, I-00161 ROME, ITALY
关键词
MATERNAL DEPRIVATION; MATERNAL REGULATION; DEVELOPMENT; STRESS; CORTICOSTERONE; ACTH;
D O I
10.1016/0031-9384(91)90001-5
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
In the following studies, we investigated the effects of 24-h maternal deprivation on the infant's hypothalamic-pituitary-adrenal system. Experiment 1 examined the effect of deprivation on the infant's corticosterone (CORT) response to adrenocorticotropin hormone (ACTH) injection. At all ages studied, deprivation resulted in a potentiation of the response. At some ages, deprived nontreated pups had higher CORT levels than nondeprived pups. Experiment 2 examined the ontogeny of the deprivation-induced stress response, and the capacity of the mother to inhibit it. From 8 days of age onwards, deprived animals showed a CORT response to saline injection that was either absent or far smaller in nondeprived pups. Saline-induced CORT secretion was diminished, or prevented, by returning the infant to its dam. Maternal reunion had no effect on ACTH-induced CORT elevations. Finally, Experiment 3 investigated the effects of deprivation over a more extended period of time. In maternally deprived pups, ACTH-induced CORT elevations persisted for at least 2 h following reunion, but by 6 h had returned to baseline. These data suggest that maternal factors are involved in the regulation of the responsiveness of the pup's hypothalamic-pituitary-adrenal system.
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收藏
页码:661 / 671
页数:11
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