BIOAVAILABILITY ASSESSMENT OF THE LIPOPHILIC BENFOTIAMINE AS COMPARED TO A WATER-SOLUBLE THIAMIN DERIVATIVE

被引：54

作者：

BITSCH, R ^{[1
]}

WOLF, M ^{[1
]}

MOLLER, J ^{[1
]}

HEUZEROTH, L ^{[1
]}

GRUNEKLEE, D ^{[1
]}

机构：

[1] EVANGEL HOSP ST JOHANNISSTIFT,PADERBORN,GERMANY

来源：

ANNALS OF NUTRITION AND METABOLISM | 1991年 / 35卷 / 05期

关键词：

ALLITHIAMINES; BENFOTIAMINE; THIAMIN MONONITRATE; BIOAVAILABILITY; TRANSKETOLASE; THIAMIN ABSORPTION;

D O I：

10.1159/000177659

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The bioequivalence of thiamin in 2 therapeutically used preparations was tested in 10 healthy young men. Thiamin was orally administered either as lipophilic benfotiamine or as water-soluble thiamin mononitrate. Biokinetic data, measured as area under the curve and maximal concentration in plasma and hemolysate after ingestion, demonstrated a significantly improved bioavailability from the lipophilic derivative despite an ingested dose of only 40% as compared with the water-soluble salt. A superior cellular efficacy of benfotiamine was also concluded from the short-term stimulation of the thiamin-dependent transketolase activity in erythrocytes.

引用

页码：292 / 296

页数：5

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