COMPUTERIZED IMAGE-ANALYSIS OF NUCLEAR ENLARGEMENT ASSAY IN HELA-CELLS

被引：0

作者：

RIZZI, R

RE, F

CHIESARA, E

机构：

来源：

ATLA-ALTERNATIVES TO LABORATORY ANIMALS | 1991年 / 19卷 / 01期

关键词：

COMPUTERIZED IMAGE ANALYSIS; NUCLEAR ENLARGEMENT ASSAY; CHEMICAL CARCINOGENESIS; SHORT-TERM TEST;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been observed that cells often respond to carcinogens by nuclear enlargement. For this reason, new morphometric approaches have been developed to evaluate cell modifications in pre-carcinogenesis assays. Morphometric computerised automatic analysis, with original software, was performed on HeLa cells treated with various compounds (hydroxyurea, dimethylnitrosamine, N-methyl-N'-nitro-nitrosoguanidine and cyclophosphamide) to evaluate nuclear size changes.

引用

页码：41 / 47

页数：7

共 12 条

[1]

BANERJEE MR, 1965, J NATL CANCER I, V35, P585

[2]

CHRISTIE GS, 1961, LAB INVEST, V10, P729

[3]

FINCH RA, 1980, TOXICOLOGY, V5, P145

[4] SUPPRESSION OF HELA-CELL GROWTH AND INCREASE IN NUCLEAR SIZE BY CHEMICAL CARCINOGENS - POSSIBLE SCREENING METHOD [J].