EXPRESSION OF THE X-INACTIVATION-ASSOCIATED GENE XIST DURING SPERMATOGENESIS

被引：126

作者：

SALIDO, EC

YEN, PH

MOHANDAS, TK

SHAPIRO, LJ

机构：

[1] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,SCH MED,DEPT PEDIAT,TORRANCE,CA 90509

[2] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,SCH MED,DEPT BIOL CHEM,TORRANCE,CA 90509

[3] UNIV LA LAGUNA,SCH MED,DEPT PATHOL,E-38071 TENERIFE,SPAIN

来源：

NATURE GENETICS | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1038/ng1192-196

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mammalian X-chromosome inactivation is thought to be controlled by the X inactivation centre (XIC, X-controlling element -Xce- in mice). A human gene, XIST and its mouse counterpart, Xist, which map to the XIC/Xce, are expressed exclusively from inactive X chromosomes, suggesting their involvement in the process of X-inactivation. We now report the presence of Xist/XIST transcripts in newborn and adult mouse testes, and in human testicular tissue with normal spermatogenesis, but not in the testes of patients who lack germ cells. Our results indicate that while the X chromosome in males is active in somatic cells, it undergoes inactivation during spermatogenesis.

引用

页码：196 / 199

页数：4

共 29 条

[1] SPERMATOGENIC CELLS OF PREPUBERAL MOUSE - ISOLATION AND MORPHOLOGICAL CHARACTERIZATION [J].