ANTIPSYCHOTIC DRUG-ACTION IN SCHIZOPHRENIC-PATIENTS - EFFECT ON CORTICAL DOPAMINE METABOLISM AFTER LONG-TERM TREATMENT

被引：102
作者：
BACOPOULOS, NC
SPOKES, EG
BIRD, ED
ROTH, RH
机构：
[1] MCLEAN HOSP,BELMONT,MA 02178
[2] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510
[3] ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
来源：
SCIENCE | 1979年 / 205卷 / 4413期
关键词：
D O I：
10.1126/science.38504
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with antipsychotic drugs.
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页码：1405 / 1407
页数：3
相关论文
共 34 条
[1]   AMPHETAMINE PSYCHOSIS - BEHAVIORAL AND BIOCHEMICAL ASPECTS [J].
ANGRIST, B ;
SATHANANTHAN, G ;
WILK, S ;
GERSHON, S .
JOURNAL OF PSYCHIATRIC RESEARCH, 1974, 11 :13-23
[2]   BEHAVIORAL EFFECTS OF L-DOPA IN SCHIZOPHRENIC PATIENTS [J].
ANGRIST, B ;
SATHANANTHAN, G ;
GERSHON, S .
PSYCHOPHARMACOLOGIA, 1973, 31 (01) :1-12
[3]   REGIONAL SENSITIVITY OF PRIMATE BRAIN DOPAMINERGIC-NEURONS TO HALOPERIDOL - ALTERATIONS FOLLOWING CHRONIC TREATMENT [J].
BACOPOULOS, NG ;
BUSTOS, G ;
REDMOND, DE ;
BAULU, J ;
ROTH, RH .
BRAIN RESEARCH, 1978, 157 (02) :396-401
[4]   DOPAMINERGIC INNERVATION OF RAT PREFRONTAL CORTEX - FLUORESCENCE HISTOCHEMICAL STUDY [J].
BERGER, B ;
THIERRY, AM ;
TASSIN, JP ;
MOYNE, MA .
BRAIN RESEARCH, 1976, 106 (01) :133-145
[5]   MEDICAL-TREATMENT OF MENTAL-ILLNESS [J].
BERGER, PA .
SCIENCE, 1978, 200 (4344) :974-981
[6]  
Bowers M B Jr, 1977, Adv Biochem Psychopharmacol, V16, P639
[7]   FURTHER STUDIES ON MECHANISM OF ANTIPSYCHOTIC ACTION - POTENTIATION BY ALPHA-METHYLTYROSINE OF THIORIDAZINE EFFECTS IN CHRONIC SCHIZOPHRENICS [J].
CARLSSON, A ;
ROOS, BE ;
WALINDER, J ;
SKOTT, A .
JOURNAL OF NEURAL TRANSMISSION, 1973, 34 (02) :125-132
[8]   ANTIPSYCHOTIC-DRUGS, NEUROTRANSMITTERS, AND SCHIZOPHRENIA [J].
CARLSSON, A .
AMERICAN JOURNAL OF PSYCHIATRY, 1978, 135 (02) :164-173
[9]  
Connell PH, 1958, AMPHETAMINE PSYCHOSI
[10]   DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS [J].
CREESE, I ;
BURT, DR ;
SNYDER, SH .
SCIENCE, 1976, 192 (4238) :481-483
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