ANTIPSYCHOTIC DRUG-ACTION IN SCHIZOPHRENIC-PATIENTS - EFFECT ON CORTICAL DOPAMINE METABOLISM AFTER LONG-TERM TREATMENT

被引：102
作者：
BACOPOULOS, NC
SPOKES, EG
BIRD, ED
ROTH, RH
机构：
[1] MCLEAN HOSP,BELMONT,MA 02178
[2] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510
[3] ADDENBROOKES HOSP,DEPT NEUROL SURG & NEUROL,CAMBRIDGE CB2 2QQ,ENGLAND
来源：
SCIENCE | 1979年 / 205卷 / 4413期
关键词：
D O I：
10.1126/science.38504
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with antipsychotic drugs.
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页码：1405 / 1407
页数：3
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