DIFFERENT RESPONSE OF TH1 CELLS FOR STIMULATION WITH ANTI-CD3 ANTIBODIES

被引：24

作者：

LOHOFF, M ^{[1
]}

SCHMITT, E ^{[1
]}

RESKEKUNZ, AB ^{[1
]}

ROLLINGHOFF, M ^{[1
]}

机构：

[1] UNIV MAINZ,INST IMMUNOL,W-6500 MAINZ,GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 03期

关键词：

D O I：

10.1002/eji.1830200328

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this report, evidence is provided for a further subdivision of CD4+ T helper cell lines. The earlier definition of the TH1 and TH2 subtypes was confirmed by their differential response to interleukin (IL) 1. An additional subdivision of the TH1 subset was revealed when TH1 cell lines were costimulated with anti‐CD3 antibodies and IL2. The IL2‐induced proliferation of three of the resulting TH1 lines was blocked by anti‐CD3 antibodies. By contrast, no such block was observed in a fourth TH1 cell line. In all four lines anti‐CD3 triggering caused production of IL 2. The block of proliferation was reversed neither by antigen‐presenting cells nor by phorbol 12‐myristate 13‐acetate, a protein kinase C activator. In all TH2 cells, however, anti‐CD3 triggering led to IL4 production, but had only marginal effects on IL2‐induced cell proliferation. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

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页码：653 / 658

页数：6

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