Vascular Antiaggregatory Effects Of Blood Vessels On Erythrocytes In Patients With Impaired Glucose Tolerance

The widespread prevalence of thrombosis in patients with impaired glucose tolerance is currently associated with the presence of vasopathy. Because of the high incidence of glucose intolerance in developed countries, it is of great interest to assess the status of this category of patients with the level of vascular control over aggregation by the most numerous cells of the blood, erythrocytes. The aim of the work is to assess the level of disaggregation capacity of blood vessels in relation to erythrocytes in patients with impaired glucose tolerance. 42 patients with impaired glucose tolerance of the second adulthood were examined. The control group consisted of 26 healthy people of the same age. The study uses biochemical, hematological and statistical methods of investigation. In patients in erythrocytes, an excess of cholesterol, a decrease in total phospholipids, and activation of lipid peroxidation processes were detected. High spontaneous aggregation of erythrocytes was also found in patients. Weakened vascular control over erythrocyte aggregation in all patients. The attenuation of disaggregating vascular effects on erythrocytes is a consequence of metabolic disturbances arising in violation of glucose tolerance, a decrease in the lumen of the vessels due to spasm and active lipid peroxidation. The vasopathy present in the examined patients sharply increased their risk of thrombosis leading to disability and death.