MICROGRAPHIA IN PARKINSONS-DISEASE

被引：31
|
作者：
CONTRERASVIDAL, JL
TEULINGS, HL
STELMACH, GE
机构：
[1] Motor Control Laboratory, Department of Exercise Science, Arizona State University, Tempe, AZ
来源：
NEUROREPORT | 1995年 / 6卷 / 15期
关键词：
BASAL GANGLIA; NEURAL NETWORK; PARKINSONS DISEASE; MICROGRAPHIA; DOPAMINE; HANDWRITING; NEUROTRANSMITTER DYNAMICS IN PARKINSONS DISEASE;
D O I：
10.1097/00001756-199510010-00032
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
A computational neural model of movement production in normal and Parkinson's disease (PD) is used to provide a neural account for the source of micrographia in PD handwriting. It is hypothesized that smaller than normal pallido-thalamic signals, due to dopamine depletion, are responsible for the observed overall smallness, slowness and variability in PD handwriting. Experimental data from PD patients that show micrographia support this hypothesis and imply the functional segregation of basal ganglia neural populations.
引用
收藏
页码：2089 / 2092
页数：4
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