RECOMBINANT INTERLEUKIN-5 INDUCES INVIVO AIRWAY HYPERRESPONSIVENESS TO HISTAMINE IN GUINEA-PIGS

被引:17
|
作者
VANOOSTERHOUT, AJM [1 ]
VANARK, I [1 ]
HOFMAN, G [1 ]
SAVELKOUL, HFJ [1 ]
NIJKAMP, FP [1 ]
机构
[1] ERASMUS UNIV ROTTERDAM, DEPT IMMUNOL, 3000 DR ROTTERDAM, NETHERLANDS
关键词
HYPERRESPONSIVENESS; RESPIRATORY AIRWAYS; INTERLEUKIN-5; EOSINOPHILS; ASTHMA;
D O I
10.1016/0014-2999(93)90475-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Interleukin-5-producing CV-1 cells were encapsulated in alginate and injected i.p. in guinea pigs (4 x 10(6)/animal). These cells produced approximately 8 ng interleukin-5 per 4 x 10(6) cells per day. Airway hyperresponsiveness to histamine in vivo was observed 3 and 7 days after administration. The increase in lung resistance after intravenous administration of histamine to guinea pigs was significantly potentiated, by approximately 70 to 90% in interleukin-5-treated animals. In animals treated with antibody to interleukin-5, the administration of interleukin-5-producing CV-1 cells did not induce hyperresponsiveness. The percentage of eosinophils in broncho-alveolar lavage fluid was increased by 100% at 7 days but not at 3 days after administration of interleukin-5-producing CV-1 cells. Antibody to interleukin-5 prevented the broncho-alveolar lavage eosinophilia at 7 days after interleukin-5 administration. It can be concluded that interleukin-5 induces broncho-alveolar lavage eosinophilia and airway hyperresponsiveness and that these phenomena do not occur simultaneously. These data suggest a role for interleukin-5 in the development of airway hyperresponsiveness in bronchial asthma.
引用
收藏
页码:379 / 383
页数:5
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