Ciona as a Simple Chordate Model for Heart Development and Regeneration

被引:27
作者
Anderson, Heather Evans [1 ]
Christiaen, Lionel [2 ]
机构
[1] Winthrop Univ, Dept Biol, Rock Hill, SC 29732 USA
[2] NYU, Dept Biol, New York, NY 10003 USA
基金
美国国家卫生研究院;
关键词
Ciona; cardiac development; cardiac cell specification; cardiac regeneration;
D O I
10.3390/jcdd3030025
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cardiac cell specification and the genetic determinants that govern this process are highly conserved among Chordates. Recent studies have established the importance of evolutionarily-conserved mechanisms in the study of congenital heart defects and disease, as well as cardiac regeneration. As a basal Chordate, the Ciona model system presents a simple scaffold that recapitulates the basic blueprint of cardiac development in Chordates. Here we will focus on the development and cellular structure of the heart of the ascidian Ciona as compared to other Chordates, principally vertebrates. Comparison of the Ciona model system to heart development in other Chordates presents great potential for dissecting the genetic mechanisms that underlie congenital heart defects and disease at the cellular level and might provide additional insight into potential pathways for therapeutic cardiac regeneration.
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页数:20
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