IN-VITRO EFFECTS OF BRODIMOPRIM ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS - PRELIMINARY-RESULTS

被引：3
|
作者：
MINI, E
NOVELLI, A
CORONNELLO, M
FALLANI, S
PESCIULLESI, A
PERITI, P
机构：
来源：
JOURNAL OF CHEMOTHERAPY | 1993年 / 5卷 / 06期
关键词：
D O I：
10.1080/1120009X.1993.11741104
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The in vitro effects of brodimoprim and trimethoprim on the functions of human polymorphonuclear (PMN) leukocytes have been studied comparatively evaluating chemotaxis, phagocytosis and production of superoxide anion. No significant effects of both diaminopyrimidines on chemotaxis and phagocytic activity of PMNs have been observed while both brodimioprim and trimethoprim enhanced the oxidative burst. A synergistic activity between the host immune system and the direct antimicrobial action of brodimoprim may occur while using this diaminopyrimidine in vivo.
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页码：499 / 501
页数：3
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