LYMPHOCYTE-TRANSFORMATION ABNORMALITIES IN BOVINE IMMUNODEFICIENCY-LIKE VIRUS-INFECTED CALVES

被引：44

作者：

MARTIN, SJ ^{[1
]}

ONEILL, TP ^{[1
]}

BILELLO, JA ^{[1
]}

EISEMAN, JL ^{[1
]}

机构：

[1] VET ADM MED CTR,RES SERV,BALTIMORE,MD 21218

来源：

IMMUNOLOGY LETTERS | 1991年 / 27卷 / 02期

关键词：

ACQUIRED IMMUNODEFICIENCY SYNDROME; AIDS; BOVINE IMMUNODEFICIENCY-LIKE VIRUS; LYMPHOCYTE TRANSFORMATION; LYMPHOCYTE STIMULATION;

D O I：

10.1016/0165-2478(91)90132-T

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bovine immunodeficiency-like virus (BIV) is a lentiviral pathogen of cattle which is genetically and antigenically related to the human immunodeficiency virus (HIV-1). To determine the impact of BIV infection on the bovine immune system we studied the lymphocyte transformation responses of male Holstein calves inoculated with BIV strain R-29 to three mitogens: pokeweed mitogen (PWM), concanavalin A (Con A), and phytohemagglutinin (PHA) at two and six months post-infection. By six months post-inoculation the response to all three mitogens was diminished compared to control animals and remained depressed 10 months post-inoculation. These results demonstrate that a functional impairment of lymphocytes can be observed early in the course of BIV infection, and prior to the onset of overt clinical disease.

引用

页码：81 / 84

页数：4

共 22 条

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[12] IMMUNOLOGICAL STUDIES IN THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME .2. ACTIVE SUPPRESSION OR INTRINSIC DEFECT - INVESTIGATED BY MIXING AIDS CELLS WITH HLA-DR IDENTICAL NORMAL-CELLS [J].