NOREPINEPHRINE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN GENETICALLY EPILEPSY-PRONE AND KINDLED RATS

被引：17
|
作者：
YOURICK, DL
LAPLACA, MC
MEYERHOFF, JL
机构：
[1] Department of Medical Neurosciences, Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington
来源：
BRAIN RESEARCH | 1991年 / 551卷 / 1-2期
关键词：
INOSITOL PHOSPHATE; NORADRENALINE; CEREBRAL CORTEX; AMYGDALA/PYRIFORM CORTEX; HIPPOCAMPUS; KINDLING; EPILEPSY; RAT;
D O I：
10.1016/0006-8993(91)90948-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy.
引用
收藏
页码：315 / 318
页数：4
相关论文
共 50 条
  • [21] Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats
    Bing Shi
    James E. Heavner
    Charles E. Reigel
    Y. James Kao
    Alan D. Kaye
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2000, 362 : 402 - 405
  • [22] Sleep, temperature, activity, and prolactin phenotypes of genetically epilepsy-prone rats
    Toth, Linda A.
    Wang, Jia
    Bosgraaf, Christine
    Reichensperger, Joel
    Hughes, Larry F.
    Faingold, Carl L.
    COMPARATIVE MEDICINE, 2006, 56 (05) : 402 - 415
  • [23] Alterations in brain and pituitary β-endorphin content in genetically epilepsy-prone rats
    Carr, JA
    Carpenter, AM
    D'Souza, MM
    Elmore, AR
    Lovering, AT
    Reigel, CE
    EPILEPSY RESEARCH, 1998, 31 (02) : 113 - 122
  • [24] Convulsant effects of some xanthine derivatives in genetically epilepsy-prone rats
    De Sarro A.
    Grasso S.
    Zappalà M.
    Nava F.
    De Sarro G.
    Naunyn-Schmiedeberg's Archives of Pharmacology, 1997, 356 (1) : 48 - 55
  • [25] SENSITIVITY OF CEREBELLAR PURKINJE NEURONS TO NOREPINEPHRINE (NE) IN THE GENETICALLY EPILEPSY-PRONE RAT (GEPR)
    GOULD, EM
    CRAIG, CR
    FLEMING, WW
    TAYLOR, DA
    FASEB JOURNAL, 1991, 5 (05): : A1211 - A1211
  • [26] Convulsant effects of some xanthine: Derivatives in genetically epilepsy-prone rats
    DeSarro, A
    Grasso, S
    Zappala, M
    Nava, F
    DeSarro, G
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 356 (01) : 48 - 55
  • [27] THE BENZODIAZEPINE RECEPTOR IN CULTURED ASTROCYTES FROM GENETICALLY EPILEPSY-PRONE RATS
    DUCIS, I
    NORENBERG, LOB
    NORENBERG, MD
    BRAIN RESEARCH, 1990, 531 (1-2) : 318 - 321
  • [28] Effect of precollicular transection on audiogenic seizures in genetically epilepsy-prone rats
    Browning, RA
    Wang, C
    Nelson, DK
    Jobe, PC
    EXPERIMENTAL NEUROLOGY, 1999, 155 (02) : 295 - 301
  • [29] SEIZURE CHARACTERISTICS OF SUCCESSIVE GENERATIONS OF GENETICALLY EPILEPSY-PRONE RATS (GEPRS)
    JOBE, PC
    DAILEY, JW
    MISHRA, PK
    REIGEL, CE
    FEDERATION PROCEEDINGS, 1986, 45 (03) : 676 - 676
  • [30] TYPES OF SEROTONERGIC ABNORMALITIES CHARACTERISTIC OF GENETICALLY EPILEPSY-PRONE RATS (GEPRS)
    DAILEY, JW
    REIGEL, CE
    WOODS, TW
    PENNY, JE
    JOBE, PC
    FEDERATION PROCEEDINGS, 1985, 44 (04) : 1107 - 1107
12345