NOREPINEPHRINE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN GENETICALLY EPILEPSY-PRONE AND KINDLED RATS

被引：17
|
作者：
YOURICK, DL
LAPLACA, MC
MEYERHOFF, JL
机构：
[1] Department of Medical Neurosciences, Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington
来源：
BRAIN RESEARCH | 1991年 / 551卷 / 1-2期
关键词：
INOSITOL PHOSPHATE; NORADRENALINE; CEREBRAL CORTEX; AMYGDALA/PYRIFORM CORTEX; HIPPOCAMPUS; KINDLING; EPILEPSY; RAT;
D O I：
10.1016/0006-8993(91)90948-U
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Genetically epilepsy-prone rats (GEPR-9) and kindled rats have reduced noradrenergic function. In the present study, norepinephrine-stimulated accumulation of inositol phosphates was reduced in cerebral cortex of GEPR-9 and kindled rats when compared to control and non-kindled rats, respectively. No such reduction was found in amygdala/pyriform cortex and hippocampus. These results support the hypothesis that cortical noradrenergic and associated second messenger systems are impaired in epilepsy.
引用
收藏
页码：315 / 318
页数：4
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