REDUCED LEVELS OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN HUMAN BRAIN VESSELS AFTER SUBARACHNOID HEMORRHAGE

被引：44
作者：
EDVINSSON, L
EKMAN, R
JANSEN, I
MCCULLOCH, J
MORTENSEN, A
UDDMAN, R
机构：
[1] UNIV GLASGOW,WELLCOME NEUROSCI GRP,GLASGOW G12 8QQ,SCOTLAND
[2] UNIV LUND,DEPT INTERNAL MED,S-22101 LUND,SWEDEN
[3] UNIV LUND,DEPT NEUROCHEM,S-22101 LUND,SWEDEN
[4] UNIV LUND,DEPT EXPTL RES,S-22101 LUND,SWEDEN
[5] UNIV LUND,DEPT OTORHINOLARYNGOL,S-22101 LUND,SWEDEN
[6] KOBENHAVENS AMTS SYGEHUS,DEPT NEUROSURG,GLOSTRUP,DENMARK
来源：
NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期
基金：
英国惠康基金;
关键词：
SUBARACHNOID HEMORRHAGE; HUMAN; CEREBRAL CIRCULATION; RADIOIMMUNOASSAY; HPLC; INVITRO PHARMACOLOGY; CALCITONIN GENE-RELATED PEPTIDE;
D O I：
10.1016/0304-3940(91)90672-G
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Human cerebral vessels were found to contain calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI) which in the reversed phase HPLC co-eluted with authentic human alpha-CGRP. The level was significantly lower in arteries removed from patients who had died from a subarachnoid haemorrhage (SAH) as compared to patients who died of a coronary infarction. On a molar basis human alpha-CGRP was more potent than human beta-CGRP to dilate human brain vessels and to dilate vasoconstriction elicited by whole blood. It is suggested that the trigemino-cerebrovascular system storing CGRP-LI may be involved in the pathophysiology of SAH in man.
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收藏
页码：151 / 154
页数：4
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