SYNTHESIS, REACTIONS, AND C-13 FT NMR-SPECTROSCOPY OF POLYMER-BOUND STEROIDS

被引：29

作者：

BLOSSEY, EC ^{[1
]}

CANNON, RG ^{[1
]}

FORD, WT ^{[1
]}

PERIYASAMY, M ^{[1
]}

MOHANRAJ, S ^{[1
]}

机构：

[1] OKLAHOMA STATE UNIV,DEPT CHEM,STILLWATER,OK 74078

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 15期

关键词：

D O I：

10.1021/jo00302a035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dehydrocholic acid (3,7,12-trioxo-β-cholanoic acid) and cholic acid (3α,7α,12α-trihydroxy-5β-cholanoic acid) were attached, via their carboxyl groups, to chloromethylated poly(styrene-2% divinylbenzene) to form the polymers 1 and 6, respectively. Synthetic transformations of the bound steroids containing the carbonyl and hydroxyl groups and esterification of hydroxyl functions was obtained by 13C NMR spectra of solvent swollen polymer gels. The 13C NMR spectra of the bound steroids represents a major advance in the analysis of polymer-supported species, permitting structural assignments to be made, on a qualitative basis, of the intact polymer without resorting to cleavage reactions of the bound material. © 1990, American Chemical Society. All rights reserved.

引用

页码：4664 / 4668

页数：5

共 30 条

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