BIO-ELIMINATION AND ORGAN RETENTION PROFILE OF BENZANTHRONE IN SCORBUTIC AND NON-SCORBUTIC GUINEA-PIGS

被引：7

作者：

DAS, M

GARG, K

SINGH, GB

KHANNA, SK

机构：

[1] Dyes and Food Adulterant Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, 226 001, Mahatma Gandhi Marg

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)91050-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retention and bio-elimination of benzanthrone (BA) in scorbutic and non-scorbutic guinea pigs was investigated to understand the protective role of ascorbic acid. Oral intubation of 14C-BA to scorbutic and non-scorbutic guinea pigs showed a total recovery of around 91% radioactivity through urine, faeces and tissues. Recovery of radiolabelled BA through urine (28%) and faeces (22%) up to 96 hrs averaged 50%, whereas residual radioactivity in liver and testis experienced a recovery of 29% in scorbutic animals. In non-scorbutic animals there was an increased recovery of radioactivity through urine (37%) and faeces (31%) with a decrease in retention (10%) in liver and testis. These results suggest that ascorbic acid facilitates the mobilization and bio-elimination of BA and thereby can decrease the toxicity of the compound. © 1991.

引用

页码：1405 / 1412

页数：8

共 20 条

[1] DAS M, 1989, BIOCHEM INT, V18, P1237
[2] EFFECTS OF INDUCTION OF CYTOCHROME-P-450 ENZYMES ON THE CONCENTRATION OF FOREIGN COMPOUNDS AND THEIR METABOLITES AND ON THE TOXICOLOGICAL EFFECTS OF THESE COMPOUNDS
GILLETTE, JR
[J]. DRUG METABOLISM REVIEWS, 1979, 10 (01) : 59 - 87
[3] INSITU EMISSION LEVELS OF CARCINOGENIC AND MUTAGENIC COMPOUNDS FROM DIESEL AND GASOLINE-ENGINE VEHICLES ON AN EXPRESSWAY
HANDA, T
YAMAUCHI, T
SAWAI, K
YAMAMURA, T
KOSEKI, Y
ISHII, T
[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1984, 18 (12) : 895 - 902
[4] Horakova E, 1966, Prac Lek, V18, P78
[5] PROTECTIVE EFFECT OF ASCORBIC-ACID ON HEPATOTOXICITY CAUSED BY SODIUM NITRITE PLUS AMINOPYRINE
KAMM, JJ
DASHMAN, T
CONNEY, AH
BURNS, JJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) : 747 - 749
[6] KLAASEN CD, 1986, TOXICOLOGY BASIC SCI, P33
[7] LUKIENKO PI, 1985, ARCH TOXICOL S, V8, P379
[8] MARHOLD JV, 1983, ENCY OCCUPATIONAL HL, P256
[9] OSER M, 1965, HAWKS PHYSL, P1472
[10] Peyer KH, 1943, ARCH INTERN MED, V71, P315, DOI 10.1001/archinte.1943.00210030016002

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