ULTRASTRUCTURE OF TELANGIECTATIC OSTEOSARCOMA

被引:12
作者
ROESSNER, A [1 ]
HOBIK, HP [1 ]
IMMENKAMP, M [1 ]
GRUNDMANN, E [1 ]
机构
[1] UNIV MUNSTER,ORTHOPAED CLIN,D-4400 MUNSTER,FED REP GER
关键词
Electron microscopy; Histogenesis; Telangiectatic osteosarcoma;
D O I
10.1007/BF00401013
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent investigations have shown that telangiectatic osteosarcoma has a poorer prognosis than other osteosarcomas. To elucidate the histogenesis of TOS two cases were investigated on the electron microscopic level. The results show that besides anaplastic, osteoblast-like, and fibroblast-like tumor cells angiosarcomatous components can be observed in this malignant bone tumor, which are characterized by endothelial cells with pinocytotic vesicles, tight intercellular junctions, fine fibrils, and so-called Weibel-Palade bodies in their cytoplasm. From these results, it is concluded that telangiectatic osteosarcoma is derived from multipotent mesenchymal cells with potential differentiation into various directions, such as osteoblast-like cells, endothelial cells, and fibroblast-like cells. © 1979 Springer-Verlag.
引用
收藏
页码:197 / 207
页数:11
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