SURVIVAL ANALYSIS TECHNIQUES IN ANGINA-PECTORIS TRIALS

被引：8
作者：
BRISTOL, DR
CASTELLANA, JV
机构：
[1] Development Department, CIBA-GEIGY Corporation, Summit, New Jersey, 07901
来源：
STATISTICS IN MEDICINE | 1990年 / 9卷 / 03期
关键词：
D O I：
10.1002/sim.4780090312
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The variable ‘walking time to moderate angina’ on an exercise stress test is the primary means to judge the efficacy of new treatments for angina pectoris. Unfortunately, ‘walking time to moderate angina’; is often censored by fatigue or other reasons for premature termination of the exercise stress test. If time to fatigue is not treatment‐dependent, we propose use of survival analysis techniques in such trials. We present an example from a placebo‐controlled multicentre clinical trial and results of simulations that compare various methods of analysis. Copyright © 1990 John Wiley & Sons, Ltd.
引用
收藏
页码：293 / 299
页数：7
相关论文
共 21 条
  • [1] Bruce R.A., Hornsten T.R., Exercise stress testing in evaluation of patients with ischemic heart disease, Progress in Cardiovascular Diseases, 11, pp. 371-380, (1969)
  • [2] Bruce R.A., Exercise testing of patients with coronary artery disease: principles and normal standards of evaluation, Annals of Clinical Research, 3, pp. 323-332, (1971)
  • [3] Redwood D.R., Rosing D.R., Goldstein R.E., Beiser G.D., Epstein S.E., Importance of the design of an exercise protocol in the evaluation of patients with angina pectoris, Circulation, 43, pp. 618-628, (1971)
  • [4] (1975)
  • [5] Guidelines for the Clinical Evaluation of Anti‐Anginal Drugs, (1977)
  • [6] Subramanian V.B., Bowles M.J., Khurmi N.S., Davies A.B., Raftery E.B., Randomized double‐blind comparison of verapamil and nifedipine in chronic stable angina, American Journal of Cardiology, 50, pp. 696-702, (1982)
  • [7] Miller A.J., Kaplan B.M., Upton M.T., Grais J.M., Abrams D.L., Treadmill exercise testing in hypertensive patients treated with hydrochlorothiazide and beta‐blocking drugs, Journal of the American Medical Association, 250, pp. 67-70, (1983)
  • [8] Starling M.R., Moody M., Crawford M.H., Levi B., O'Rourke R.A., Repeat treadmill exercise testing: variability of results in patients with angina pectoris, American Heart Journal, 78, pp. 298-303, (1984)
  • [9] Reichek N., Priest C., Zimrin D., Chandler T., Sutton M.S.J., Antianginal effects of nitroglycerin patches, American Journal of Cardiology, 54, pp. 1-7, (1984)
  • [10] Epstein S.E., Redwood D.R., Goldstein R.E., Beiser G.D., Rosing D.R., Glancy D.L., Reis R.L., Stinson E.B., Angina pectoris: pathophysiology, evaluation, and treatment, Annals of Internal Medicine, 75, pp. 263-296, (1971)
123