CONFORMATIONAL ASPECTS OF CARBAMATES IN INHIBITION OF HILL REACTION

被引：11

作者：

BOOTS, MR

机构：

[1] Agricultural Chemical Division, Kansas City Laboratory, Gulf Research and Development Company, Merriarn

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of linear and cyclic carbamates (substituted 4H-3, 1-benzoxazin-2-oues) was prepared and investigated as inhibitors of the Hill reaction in isolated chloroplasts. These were chosen to investigate the conformational requirements of the carbamate group during binding to the receptor. The cyclic compounds were inactive while the linear carbamates exhibited activity. These results are discussed in terms of the conformational preference of the carbamate group, over-all molecular geometry, metabolic inactivation, and steric factors. © 1969, American Chemical Society. All rights reserved.

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页码：426 / &

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