STRUCTURE AND SEQUENCE OF THE GENE ENCODING THE ALPHA-SUBUNIT OF RAT TRANSLATION INITIATION FACTOR-2B

被引：5
作者：
FLOWERS, KM [1 ]
MELLOR, H [1 ]
KIMBALL, SR [1 ]
JEFFERSON, LS [1 ]
机构：
[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1264卷 / 02期
关键词：
PROTEIN SYNTHESIS; INITIATION FACTOR; GENE; (RAT);
D O I：
10.1016/0167-4781(95)00160-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic initiation factor-2B (eIF-2B) is a heteropentameric guanine nucleotide exchange factor involved in the recycling of eIF-2 during the translation initiation phase of protein synthesis. The activity of eIF-2B is controlled by diverse mechanisms under a wide range of conditions. As part of our studies into the control of the expression of eIF-2B subunit mRNAs, we have isolated and characterized the rat gene encoding the alpha-subunit of eIF-2B. The gene is comprised of 9 exons which are contained within 8.5 kb of genomic DNA. A comparison of the 5'-flanking region of the gene with that of the previously isolated eIF-2B epsilon gene reveals that both possess a potential binding site for the alpha-Pal transcription factor as well as several other regions of homology.
引用
收藏
页码：163 / 167
页数：5
相关论文
共 49 条
  • [41] MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF RAT BRADYKININ B-2 RECEPTOR GENE
    WANG, DZ
    MA, JX
    CHAO, L
    CHAO, J
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1994, 1219 (01): : 171 - 174
  • [42] Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding GABPB1 gene with the occupational environment
    Xu, Pei
    Xu, Xingjie
    Liu, Jun
    Hu, Huajun
    Shen, Huajiang
    Chen, Chun
    TOXICOLOGY AND INDUSTRIAL HEALTH, 2022, 38 (04) : 193 - 200
  • [43] Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2Bε (eIF2Bε) identified in Chinese patients with vanishing white matter disease
    Leng, Xuerong
    Wu, Ye
    Wang, Xuemin
    Pan, Yanxia
    Wang, Jingmin
    Li, Jiao
    Du, Li
    Dai, Lifang
    Wu, Xiru
    Proud, Christopher G.
    Jiang, Yuwu
    JOURNAL OF HUMAN GENETICS, 2011, 56 (04) : 300 - 305
  • [44] Phosphorylation of eukaryotic translation initiation factor 2Bε by glycogen synthase kinase-3β regulates β-adrenergic cardiac myocyte hypertrophy
    Hardt, SE
    Tomita, H
    Katus, HA
    Sadoshima, J
    CIRCULATION RESEARCH, 2004, 94 (07) : 926 - 935
  • [45] Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response
    Sharma, Sonum
    Sourirajan, Anuradha
    Dev, Kamal
    3 BIOTECH, 2017, 7
  • [46] THE 5' UNTRANSLATED REGION OF ENCEPHALOMYOCARDITIS VIRUS CONTAINS A SEQUENCE FOR VERY EFFICIENT BINDING OF EUKARYOTIC INITIATION-FACTOR EIF-2/2B
    SCHEPER, GC
    THOMAS, AAM
    VOORMA, HO
    BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1089 (02) : 220 - 226
  • [47] THE 2 GENES ENCODING PROTEIN-SYNTHESIS INITIATION-FACTOR ELF-5A IN SACCHAROMYCES-CEREVISIAE ARE MEMBERS OF A DUPLICATED GENE-CLUSTER
    KANG, HA
    SCHWELBERGER, HG
    HERSHEY, JWB
    MOLECULAR & GENERAL GENETICS, 1992, 233 (03): : 487 - 490
  • [48] MOLECULAR-STRUCTURE OF THE SWA2 GENE ENCODING AN AMY1-RELATED ALPHA-AMYLASE FROM SCHWANNIOMYCES-OCCIDENTALIS
    CLAROS, MG
    ABARCA, D
    FERNANDEZLOBATO, M
    JIMENEZ, A
    CURRENT GENETICS, 1993, 24 (1-2) : 75 - 83
  • [49] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells
    Suzuki, T
    Koyama, Y
    Ichikawa, H
    Tsushima, K
    Abei, K
    Hayakawa, S
    Kuruto-Niwa, R
    Nozawa, R
    Isemura, M
    CELL STRUCTURE AND FUNCTION, 2005, 30 (1-2) : 1 - 6
12345