HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, INTERFERON-GAMMA-NAEMIA AND EPSTEIN-BARR-VIRUS INVOLVEMENT

被引：78

作者：

IMASHUKU, S ^{[1
]}

HIBI, S ^{[1
]}

FUJIWARA, F ^{[1
]}

IKUSHIMA, S ^{[1
]}

TODO, S ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT PAEDIAT,KYOTO,JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 88卷 / 03期

关键词：

HEMOPHAGOCYTIC SYNDROME; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; CYTOKINE; INTERFERON-GAMMA; EPSTEIN-BARR VIRUS;

D O I：

10.1111/j.1365-2141.1994.tb05095.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To clarify the correlation between Epstein-Barr virus (EBV) involvement and hypercytokinaemia in haemophagocytic lymphohistiocytosis (HLH), we analysed serum interferon-gamma levels and EBV-DNA in biological specimens obtained from 25 HLH cases (23 children and two adults). We found that HLH patients showed a wide range of serum IFN-gamma levels from 0.2 to 1300 U/ml, with a median 126 U/ml for EBV-DNA-positive (n = 9) and 4.5 U/ml for EBV-DNA-negative (n = 16) groups. The latter group could be classified further into a group with hyper-IFN-gamma-naemia (>4.5 U/ml) (n = 8) and a group without hyper-IFN-gamma-naemia (n = 8). The survival of the hyper-IFN-gamma-naemic cases was significantly poorer than non-hyper-IFN-gamma-naemic cases. We conclude that EBV is probably involved in one third of the HLH cases, all of whom show hyper-IFN-gamma-naemia, and in the half of the HLH cases with hyper-IFN-gamma-naemia who have a rapidly fatal outcome.

引用

页码：656 / 658

页数：3

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