EFFICACY OF INTRAPERITONEAL SODIUM CARBOXYMETHYLCELLULOSE IN PREVENTING POSTOPERATIVE ADHESION FORMATION

被引:0
|
作者
HEIDRICK, GW [1 ]
PIPPITT, CH [1 ]
MORGAN, MA [1 ]
THURNAU, GR [1 ]
机构
[1] UNIV OKLAHOMA,COLL MED,DEPT OBSTET & GYNECOL,OKLAHOMA CITY,OK
关键词
SODIUM CARBOXYMETHYLCELLULOSE; ADHESIONS;
D O I
暂无
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Various regimens to reduce postoperative intraperitoneal adhesion formation have been tested; however, prone has been consistently successful. The purpose of this study teas to compare the efficacy of three compounds instilled into the peritoneal cavity-32% dextran 70, 0.9% normal saline and sodium carboxymethylcellulose-to no therapy on their ability to prevent postoperative adhesion formation in the New Zealand white rabbit. Bilateral posterior uterine horn incisions and cecal and transverse colon abrasions were performed during a two-phased study on each of 25 rabbits that were randomly assigned in it blind fashion into one of Jour study groups. Two weeks postoperatively, each rabbit underwent an autopsy to assess the magnitude of intraperitoneal adhesion formation. Adhesion scores were determined by counting the number of adhesions and assigning one or two points for each thin, filmy or dense, broad adhesion. As compared to no therapy, all three substances tested significantly I educed adhesion formation. Although 32% dextran 70 and 0.9% normal saline showed similar results, the degree of adhesion formation was reduced mast significantly with sodium carboxymethylcellulose (P < .002) Sodium carboxymethylcellulose is effective in preventing postoperative adhesion formation in the New Zealand white rabbit.
引用
收藏
页码:575 / 578
页数:4
相关论文
共 50 条
  • [41] Polymers that reduce intraperitoneal adhesion formation
    Falk, K
    Holmdahl, L
    Halvarsson, M
    Larsson, K
    Lindman, B
    Bengmark, S
    BRITISH JOURNAL OF SURGERY, 1998, 85 (08) : 1153 - 1156
  • [42] Evaluation of the effectiveness of sodium hyaluronate, sesame oil, honey, and silver nanoparticles in preventing postoperative surgical adhesion formation. An experimental study
    Khorshidi, Hamid Reza
    Kasraianfard, Amir
    Derakhshanfar, Amir
    Rahimi, Siavash
    Sharifi, Ali
    Makarchian, Hamid Reza
    Ghorbanpoor, Manoochehr
    Reza Javadi, Seyed Mohammad
    ACTA CIRURGICA BRASILEIRA, 2017, 32 (08) : 626 - 632
  • [43] EFFECT OF VARIDASE IN CARBOXYMETHYLCELLULOSE JELLY ON PERITONEAL ADHESION FORMATION
    WHITTING, HW
    YOUNG, BA
    VIRCHOWS ARCHIV FUR PATHOLOGISCHE ANATOMIE UND PHYSIOLOGIE UND FUR KLINISCHE MEDIZIN, 1966, 341 (02): : 155 - &
  • [44] Endogenous versus exogenous IL-10 in postoperative intraperitoneal adhesion formation in a murine model
    Holschneider, CH
    Cristoforoni, PM
    Ghosh, K
    Punyasavatsut, M
    Abed, E
    Montz, FJ
    JOURNAL OF SURGICAL RESEARCH, 1997, 70 (02) : 138 - 143
  • [45] Effect of intraperitoneal cetuximab administration on colonic anastomosis and early postoperative adhesion formation in a rat model
    Kurt, Atilla
    Karanlik, Hasan
    Soylu, Sinan
    Ozgur, Ilker
    Soydinc, Hilal Oguz
    Duranyildiz, Derya
    Olgac, Vakur
    Sen, Fatma
    Asoglu, Oktar
    TURKISH JOURNAL OF SURGERY, 2016, 32 (03) : 157 - 161
  • [46] ADHESION PREVENTION BY SOLUTIONS OF SODIUM CARBOXYMETHYLCELLULOSE IN THE RAT .2.
    ELKINS, TE
    LING, FW
    AHOKAS, RA
    ABDELLA, TN
    HOMSEY, CA
    MALINAK, LR
    FERTILITY AND STERILITY, 1984, 41 (06) : 929 - 932
  • [47] What is the impact of intraperitoneal surfactant administration against postoperative intraabdominal adhesion formation? an experimental study
    Pala, Sehmus
    Kuloglu, Tuncay
    Atilgan, Remzi
    Ozkan, Zehra Sema
    Hancer, Serhat
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2023, 53 (06) : 1817 - 1824
  • [48] ADHESION PREVENTION BY SOLUTIONS OF SODIUM CARBOXYMETHYLCELLULOSE IN THE RAT .1.
    ELKINS, TE
    BURY, RJ
    RITTER, JL
    LING, FW
    AHOKAS, RA
    HOMSEY, CA
    MALINAK, LR
    FERTILITY AND STERILITY, 1984, 41 (06) : 926 - 928
  • [49] Utilization and Safety of Sodium Hyaluronate-Carboxymethylcellulose Adhesion Barrier
    Bashir, Shazia
    Ananth, Cande V.
    Lewin, Sharyn N.
    Burke, William M.
    Lu, Yu-Shiang
    Neugut, Alfred I.
    Herzog, Thomas J.
    Hershman, Dawn L.
    Wright, Jason D.
    DISEASES OF THE COLON & RECTUM, 2013, 56 (10) : 1174 - 1184
  • [50] The effect of ionized collagen for preventing postoperative adhesion
    Chung, Young Soo
    Park, Si-Nae
    Ko, Jae Hyung
    Bae, Sang Hee
    Lee, Song
    Shim, In Kyong
    Kim, Song Cheol
    JOURNAL OF SURGICAL RESEARCH, 2016, 205 (02) : 341 - 349