Various regimens to reduce postoperative intraperitoneal adhesion formation have been tested; however, prone has been consistently successful. The purpose of this study teas to compare the efficacy of three compounds instilled into the peritoneal cavity-32% dextran 70, 0.9% normal saline and sodium carboxymethylcellulose-to no therapy on their ability to prevent postoperative adhesion formation in the New Zealand white rabbit. Bilateral posterior uterine horn incisions and cecal and transverse colon abrasions were performed during a two-phased study on each of 25 rabbits that were randomly assigned in it blind fashion into one of Jour study groups. Two weeks postoperatively, each rabbit underwent an autopsy to assess the magnitude of intraperitoneal adhesion formation. Adhesion scores were determined by counting the number of adhesions and assigning one or two points for each thin, filmy or dense, broad adhesion. As compared to no therapy, all three substances tested significantly I educed adhesion formation. Although 32% dextran 70 and 0.9% normal saline showed similar results, the degree of adhesion formation was reduced mast significantly with sodium carboxymethylcellulose (P < .002) Sodium carboxymethylcellulose is effective in preventing postoperative adhesion formation in the New Zealand white rabbit.
机构:
UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033
RODGERS, KE
GIRGIS, W
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UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033
GIRGIS, W
DIZEREGA, GS
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UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033UNIV SO CALIF,SCH MED,DEPT OBSTET & GYNECOL,LIVINGSTON REPROD BIOL LAB,1321 N MISS RD,LOS ANGELES,CA 90033
机构:
China Med Univ, Dept Grads 98, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Dept Grads 98, Shenyang, Liaoning, Peoples R China
Zhao, Jin-Ming
Jin, Zhi-Zhong
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机构:
China Med Univ, Dept Grads 98, Shenyang, Liaoning, Peoples R ChinaChina Med Univ, Dept Grads 98, Shenyang, Liaoning, Peoples R China
Jin, Zhi-Zhong
Zhao, Qi-Zhong
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机构:
China Med Univ, Affiliated Hosp 1, Dept Emergency, Shenyang 110001, Liaoning, Peoples R ChinaChina Med Univ, Dept Grads 98, Shenyang, Liaoning, Peoples R China
机构:
Giresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Giresun Univ Educ & Res Hosp, Dept Gen Surg, TR-28952 Giresun, TurkiyeGiresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Muhtaroglu, Ali
Kamburoglu, Muhammet Burak
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机构:
Sakarya Univ Educ, Res Hosp, Dept Gen Surg, Sakarya, TurkiyeGiresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Kamburoglu, Muhammet Burak
Oter, Volkan
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机构:
Ankara City Hosp, Dept Gastroenterol Surg, Ankara, TurkiyeGiresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Oter, Volkan
Cakar, Gozde Cakirsoy
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机构:
Sakarya Univ Educ, Res Hosp, Dept Pathol, Sakarya, TurkiyeGiresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Cakar, Gozde Cakirsoy
Cakiroglu, Huseyin
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机构:
Sakarya Univ, Fac Med, Dept Med & Expt Res, Serdivan, Sakarya, TurkiyeGiresun Univ Educ, Res Hosp, Dept Gen Surg, Giresun, Turkiye
Cakiroglu, Huseyin
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机构:
Karaman, Kerem
ANNALS OF CLINICAL AND ANALYTICAL MEDICINE,
2023,
14
(03):
: 271
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275