EFFICACY OF INTRAPERITONEAL SODIUM CARBOXYMETHYLCELLULOSE IN PREVENTING POSTOPERATIVE ADHESION FORMATION

Various regimens to reduce postoperative intraperitoneal adhesion formation have been tested; however, prone has been consistently successful. The purpose of this study teas to compare the efficacy of three compounds instilled into the peritoneal cavity-32% dextran 70, 0.9% normal saline and sodium carboxymethylcellulose-to no therapy on their ability to prevent postoperative adhesion formation in the New Zealand white rabbit. Bilateral posterior uterine horn incisions and cecal and transverse colon abrasions were performed during a two-phased study on each of 25 rabbits that were randomly assigned in it blind fashion into one of Jour study groups. Two weeks postoperatively, each rabbit underwent an autopsy to assess the magnitude of intraperitoneal adhesion formation. Adhesion scores were determined by counting the number of adhesions and assigning one or two points for each thin, filmy or dense, broad adhesion. As compared to no therapy, all three substances tested significantly I educed adhesion formation. Although 32% dextran 70 and 0.9% normal saline showed similar results, the degree of adhesion formation was reduced mast significantly with sodium carboxymethylcellulose (P < .002) Sodium carboxymethylcellulose is effective in preventing postoperative adhesion formation in the New Zealand white rabbit.