SOME ANALOGS OF 1,4-DISUBSTITUTED PIPERAZINES AS HYPNOTIC AND SEDATIVE AGENTS

被引：5
|
作者：
CHILMONCZYK, Z
BOGDAL, M
ZAWORSKA, A
CYBULSKI, J
SZELEJEWSKI, W
机构：
[1] Pharmaceutical Research Institute, Warszawa, 01-793
来源：
ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 02期
关键词：
D O I：
10.1002/ardp.19953280218
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Preparation, analytical data, and biological properties such as acute toxicity, influence on spontaneous and amphetamine induced locomotor activity, hypnotic activity, influence on hexobarbital narcosis and anticonvulsant activity of new analogues of pyrimidyl piperazines - ethyl 3-[4-(2-pyrimidyl)-1-piperazinyl]-3-oxopropanoate (4), 1-[4-(2-pyrimidyl)-1-piperazinyl]-1,3-butandione (5), ethyl 3-[4-(2-pyrimidyl)-1-piperazinyl]butanoate (6) and 1-[4-(2-pyrimidyl)-1-piperazinyl]-2-acetyl-1-hexanone (7) are reported.
引用
收藏
页码：187 / 191
页数：5
相关论文
共 50 条
  • [31] Structure-enantioselectivity relationship of hypnotic-sedative 1,4-disubstituted piperazine derivatives on cellulose tris(4-methylbenzoate) chiral stationary phase
    Chilmonczyk, Z
    Ksycinska, H
    Lisowaka-Kuzmicz, M
    Jonczyk, A
    Mazgajska, M
    Jaronczyk, M
    Strzelczyk, A
    Aboul-Enein, HY
    ANALYTICA CHIMICA ACTA, 2005, 536 (1-2) : 7 - 13
  • [32] STEREODYNAMICS OF ETHYL GROUP ROTATION OF 1,4-DISUBSTITUTED TETRAETHYLBENZENES AND THEIR CHROMIUM TRICARBONYL ANALOGS
    KILWAY, KV
    SIEGEL, JS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 197 : 18 - ORGN
  • [33] SYNTHESIS OF SOME PYRIDYLAMINO-1,4-DISUBSTITUTED PHTHALAZINES
    BAUTISTA, DV
    BULLOCK, G
    HARTSTOCK, FW
    THOMPSON, LK
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (02) : 345 - 347
  • [34] DIFFERENTIATION OF 1,4-DISUBSTITUTED AND 1,5-DISUBSTITUTED IMIDAZOLES
    MATTHEWS, HR
    RAPOPORT, H
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (07) : 2297 - 2303
  • [35] Asymmetric synthesis of 1,4-disubstituted tetrahydroioquinolines
    Jullian, V
    Quirion, JC
    Husson, HP
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2000, 2000 (07) : 1319 - 1325
  • [36] Electrochemical Reduction of 1,4-Disubstituted Phthalazines
    V. V. Yanilkin
    B. I. Buzykin
    V. I. Morozov
    N. V. Nastapova
    N. I. Maksimyuk
    R. M. Eliseenkova
    Russian Journal of General Chemistry, 2001, 71 : 1636 - 1646
  • [37] A REGIOSPECIFIC SYNTHESIS OF 1,4-DISUBSTITUTED IMIDAZOLES
    SORRELL, TN
    ALLEN, WE
    JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (06): : 1589 - 1590
  • [38] A facile route to 1,4-disubstituted benzocyclobutenes
    Lab. de Synthèse Organique, URA CNRS 574, Université de Poitiers, 40, avenue du Recteur Pineau, 86022 Poitiers, France
    SYNTH. COMMUN., 15 (2615-2625):
  • [39] Regioselective synthesis of 1,4-disubstituted imidazoles
    Schmidt, Michael A.
    Eastgate, Martin D.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (05) : 1079 - 1087
  • [40] Syntheses of functionalized 1,4-disubstituted γ-carbolines
    Wynne, JH
    Stalick, WM
    JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (12): : 4845 - 4849
12345