RESOLUTION AND REGIOSELECTIVE PROTECTION OF GLUTAMIC-ACID ANALOGS .1. RESOLUTION OF DIASTEREOMERIC ALPHA-BOROXAZOLIDONE DERIVATIVES

被引：23

作者：

ACHER, F ^{[1
]}

AZERAD, R ^{[1
]}

机构：

[1] UNIV PARIS 05,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,CNRS,UNITE ASSOCIEE 400,F-75270 PARIS 06,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 04期

关键词：

D O I：

10.1016/0957-4166(94)80036-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Diastereomeric alpha-boroxazolidone gamma-phenylethylamide (or gamma-phenylethanolamide) derivatives of 2-, 3- or 4-substituted glutamic acid analogues have been separated by silicagel chromatography, resulting, after deprotection, in a practical method for the resolution of most of these unnatural amino acids.

引用

页码：731 / 744

页数：14

共 95 条

[1]

ABRAHAM A, 1909, J MED CHEM, V34, P222

[2]

ACHER F, 1991, INT J PEPT PROT RES, V37, P210

[3] OVERALL ENANTIOSELECTIVE ALPHA-ALKYLATION OF ASPARTIC AND GLUTAMIC-ACID THROUGH DILITHIUM ENOLATOCARBOXYLATES OF 2-[3-BENZOYL-2-(TERT-BUTYL)-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL]ACETIC AND 3-[3-BENZOYL-2-(TERT-BUTYL)-1-METHYL-5-OXOIMIDAZOLIDIN-4-YL]PROPIONIC ACID, RESPECTIVELY [J].