ENZYMATIC ASSAYS FOR 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXYANILINO)METHYL]QUINAZOLINE, A PROMISING NEW NON-CLASSICAL ANTIFOLATE

被引：13

作者：

HEUSNER, JJ

MCCORMACK, JJ

机构：

[1] UNIV VERMONT,VERMONT REG CANC CTR,BURLINGTON,VT 05405

[2] NCI,DIV CANC TREATMENT,MED CHEM & BIOL LAB,BETHESDA,MD 20205

[3] UNIV VERMONT,COLL MED,DEPT PHARMACOL,BURLINGTON,VT 05405

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1981年 / 70卷 / 07期

关键词：

D O I：

10.1002/jps.2600700737

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：827 / 828

页数：2

共 12 条

[1]

BERTINO JR, 1979, CANCER RES, V39, P293

[2] 2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXYANILINO)METHYL]QUINAZOLINE (TMQ), A POTENT NON-CLASSICAL FOLATE ANTAGONIST INHIBITOR .1. EFFECT ON DIHYDROFOLATE-REDUCTASE AND GROWTH OF RODENT TUMORS INVITRO AND INVIVO [J].

BERTINO, JR ;

SAWICKI, WL ;

MOROSON, BA ;

CASHMORE, AR ;

ELSLAGER, EF .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (12) :1983-1987

[3]

BROOKS RJ, 1978, CLIN CHEM, V24, P518

[4]

BURCHALL JJ, 1965, MOL PHARMACOL, V1, P126

[5]

DUCH DS, 1980, MOL PHARMACOL, V18, P100

[6]

ELSLAGER EF, 1974, LECTURES HETEROCYCLI, V2, pS97

[7]

FENLEY PR, 1977, CLIN CHEM, V23, P2139

[8]

FUTTERMAN S, 1957, J BIOL CHEM, V228, P1031

[9] 7-HYDROXYMETHOTREXATE AS A URINARY METABOLITE IN HUMAN SUBJECTS AND RHESUS-MONKEYS RECEIVING HIGH DOSE METHOTREXATE [J].

JACOBS, SA ;

STOLLER, RG ;

CHABNER, BA ;

JOHNS, DG .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (02) :534-538

[10]

MCCORMACK JJ, 1976, CHEM BIOL PTERIDINES, P125

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