IMPAIRMENT OF ENDOTHELIUM-DEPENDENT RELAXATION OF SUPERIOR MESENTERIC-ARTERY IN GENETICALLY DIABETIC WBN KOB RATS

被引：11

作者：

MIYATA, N ^{[1
]}

YAMAURA, H ^{[1
]}

TSUCHIDA, K ^{[1
]}

OKUYAMA, S ^{[1
]}

OTOMO, S ^{[1
]}

KAMATA, K ^{[1
]}

KASUYA, Y ^{[1
]}

机构：

[1] HOSHI UNIV,SCH PHARM,DEPT PHARMACOL,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1993年 / 71卷 / 3-4期

关键词：

ACETYLCHOLINE; A23187; SODIUM NITROPRUSSIDE; INDOMETHACIN; GENETICALLY DIABETIC RATS; ENDOTHELIUM-DERIVED RELAXING FACTOR;

D O I：

10.1139/y93-046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, endothelium-dependent relaxation induced by ACh remained attenuated in WBN/Kob rats. These results show that endothelium-dependent relaxation is impaired not only in thoracic aorta but also in superior mesenteric arteries in genetically diabetic rats.

引用

页码：297 / 300

页数：4

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