IMPAIRMENT OF ENDOTHELIUM-DEPENDENT RELAXATION OF SUPERIOR MESENTERIC-ARTERY IN GENETICALLY DIABETIC WBN KOB RATS

被引：11
|
作者：
MIYATA, N [1 ]
YAMAURA, H [1 ]
TSUCHIDA, K [1 ]
OKUYAMA, S [1 ]
OTOMO, S [1 ]
KAMATA, K [1 ]
KASUYA, Y [1 ]
机构：
[1] HOSHI UNIV,SCH PHARM,DEPT PHARMACOL,SHINAGAWA KU,TOKYO 142,JAPAN
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1993年 / 71卷 / 3-4期
关键词：
ACETYLCHOLINE; A23187; SODIUM NITROPRUSSIDE; INDOMETHACIN; GENETICALLY DIABETIC RATS; ENDOTHELIUM-DERIVED RELAXING FACTOR;
D O I：
10.1139/y93-046
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The endothelium-dependent relaxation of superior mesenteric arteries of Wistar and genetically diabetic WBN/Kob rats was compared. Endothelium-dependent relaxation induced by acetylcholine (ACh) and A23187 was depressed in WBN/Kob rats. Relaxation induced by sodium nitroprusside, an endothelium-independent agent, in strips from WBN/Kob rats was similar to that in strips from Wistar rats. Indomethacin (5 x 10(-6) M) enhanced the relaxation responses to ACh in strips from both WBN/Kob and Wistar rats; however, endothelium-dependent relaxation induced by ACh remained attenuated in WBN/Kob rats. These results show that endothelium-dependent relaxation is impaired not only in thoracic aorta but also in superior mesenteric arteries in genetically diabetic rats.
引用
收藏
页码：297 / 300
页数：4
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