HISTOCHEMICAL DISTRIBUTION OF CA-125 AS A PROGNOSTIC INDICATOR IN PATIENTS WITH SEROUS OVARIAN-CANCER

被引：3
作者：
BICHEL, P
JAKOBSEN, A
ORNTOFT, TF
机构：
[1] AARHUS UNIV, AARHUS KOMMUNE HOSP, INST PATHOL, DEPT CLIN CHEM, DK-8000 AARHUS, DENMARK
[2] VEJLE CENT HOSP, INST PATHOL, AARHUS, DENMARK
[3] DANISH CANC SOC, DEPT EXPTL CLIN ONCOL, AARHUS, DENMARK
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 1991年 / 1卷 / 05期
关键词：
CA-125; HISTOCHEMICAL DISTRIBUTION; OVARY CARCINOMA; PROGNOSIS;
D O I：
10.1111/j.1525-1438.1991.tb00040.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The study comprises 66 patients with stage Ill and IV serous ovarian carcinoma While the percentage of CA-125 positive cells and the staining intensity showed no correlation to patient survival, the pattern of CA-125 distribution, membranous versus cytoplasmic, was significantly correlated to survival. In accordance with other observations on switching of the antigen reaction f rom membrane to cytoplasm with increasing grade of atypia or malignancy, patients with membrane positive CA-125 tumors had a significantly better prognosis than did patients with CA-125 in the cytoplasm. Furthermore, there was excellent agreement between, on the one hand, the binding pattern of CA-125 and, on the other, the ploidy of the tumor cells and the HGI histopathologic grading index, both previously shown to be of prognostic significance.
引用
收藏
页码：199 / 204
页数：6
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