PHARMACOKINETIC BASIS OF INTRAVENOUS DRUG DELIVERY

We have seen in recent years the release of numerous intravenous anaesthetic agents whose duration of action is relatively short, thus lending themselves to administration via continuous infusion. Clinical studies have clearly demonstrated the advantages of continuous infusion over repeated bolus dosing. These two factors have prompted pump manufacturers to produce devices that simplify the administration of intravenous anaesthetics by continuous infusion. It is concentration rather than dose that results in the desired effect. Utilizing pharmacokinetic principles, it is possible to provide automated drug delivery systems whereby the device can produce a clinician-specified drug concentration. In addition, where there is an easily measurable end-point, closed-loop feedback control can be implemented automatically to control the desired parameter within a very narrow range. With this rapid development in intravenous drug delivery, it becomes imperative that clinicians familiarize themselves with these new drug delivery devices so that they can use them optimally to care for their patients. © 1991 Baillière Tindall.