EFFECTS OF ESSENTIAL FATTY-ACID CONTENTS OF LIPID EMULSIONS ON ERYTHROCYTE POLYUNSATURATED FATTY-ACID COMPOSITION IN PATIENTS ON LONG-TERM PARENTERAL-NUTRITION

被引：30

作者：

DAHLAN, W ^{[1
]}

RICHELLE, M ^{[1
]}

KULAPONGSE, S ^{[1
]}

ROSSLE, C ^{[1
]}

DECKELBAUM, RJ ^{[1
]}

CARPENTIER, YA ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,L DELOYERS LAB EXPTL SURG,40 AVE J WYBRAN,B-1070 BRUSSELS,BELGIUM

来源：

CLINICAL NUTRITION | 1992年 / 11卷 / 05期

关键词：

D O I：

10.1016/0261-5614(92)90002-8

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The effect of the long-term intravenous infusion of 2 lipid emulsions, differing in essential fatty acid (EFA) content, on fatty acid pattern of red blood cell (RBC) was investigated in 5 patients with inflammatory bowel disease. They were randomly assigned to receive daily intravenous infusion of either a soybean emulsion or a mixed medium-chain triacylglycerols (MCT): soybean emulsion, followed by the other, each for a period of 3 months. The soybean emulsion contained exclusively long-chain triacylglycerols (LCT) with 54% of C18:2n-6 and 6% of C18:3n-3. The mixed emulsion consisted of a 50:50 (w:w) mixture of soybean LCT and MCT, providing half the amount of the same EFA compared to LCT emulsion. The same phospholipid emulsifier was used in both preparations. Infusion of LCT for a 3 month period modified RBC fatty acid pattern as follows: 18:2n-6 increased, 20:4n-6 decreased as well as n-6:n-3 ratio. By contrast, infusion of MCT/LCT did not alter RBC fatty acids, and even tended to correct a pattern altered by the previous LCT infusion. The study demonstrates that soybean LCT provides an excess of C18: 2n-6 which affects the balance between RBC fatty acids in adult patients. Decreasing the intake of C18:2n-6 and C18: 3n-3, by using a mixed MCT/LCT emulsion, appears more appropriate for keeping a balanced pattern.

引用

页码：262 / 268

页数：7

共 36 条

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