OVERCOMING INHIBITION OF ANTIBODY-RESPONSES TO A MALARIA RECOMBINANT VACCINIA VIRUS CAUSED BY PRIOR EXPOSURE TO WILD-TYPE VIRUS

被引：30

作者：

ETLINGER, HM ^{[1
]}

ALTENBURGER, W ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,CENT RES UNITS,CH-4002 BASEL,SWITZERLAND

来源：

VACCINE | 1991年 / 9卷 / 07期

关键词：

RECOMBINANT VACCINIA VIRUS; ANTIBODY; EXPOSURE; WILD TYPE; MALARIA;

D O I：

10.1016/0264-410X(91)90030-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pre-injection of mice with vaccinia virus inhibited the subsequent antibody response to a recombinant polypeptide expressed by vaccinia virus. The inhibition was overcome following additional challenges with recombinant vaccinia virus. This suggests that a potential disadvantage in vaccinia-immune individuals can be circumvented and may be outweighed by the advantages of the vector.

引用

页码：470 / 472

页数：3

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